why a increase in fatty acid oxidation is an indication of diabetes mellitus?how the two are connected?and furthermore why ketaacidosis may result from diabetes mellitus? pls a simple answer will be perfect.i have a lot of books in front of me but i just need a simple explanation to remember better
Chemistry - 1 Answers
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With diabetes the cells are unable to burn enough glucose for energy (because glucose cannot get into the cells). The alternative to burning glucose for energy is to burn fatty acids for energy through beta oxidation. The 'excessive' beta oxidation of fatty acids leads to a buildup of acetyl CoA. Excess acetyl CoA is converted into ketones. Excessive levels of ketones causes 'keto acidosis'. Hope you find this helpful.
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