Why do non-insulin dependent diabetes mellitus patients exhibit hyperinsulinemia during the development of the disease state, but later stages may not?
Diabetes - 3 Answers
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1 :
Because in the early stage of the disease the pancreas is still producing insulin not all the beta cells are wiped out yet. This is called the twilight period, it may last for more than a year before more and more insulin is required to stabilize the diabetic patient.
2 :
I wish to correct the first answer. Type 1 diabetes (which is sometimes reffered to as juvenile diabetes) is INSULIN-DEPENDANT and resistancy to insulin can be developed after long years (15 years with diabetes and still don't have it). For type 2 (non-insulin dependant) the whole problem is the resistancy to insulin your organism produces. The pills they take helps the organism take in the insulin. I guess in later stages even the pills are not enough and an external source of insulin is needed. Remember that the insulin that is injected differs from the one produced by your organism, so my guess is that there is no resistancy to that insulin and it takes long years to develop one.
3 :
I wish to correct the second answer. Although what s/he says about type 1 diabetes (juvenile diabetes) being insulin dependent is correct, what s/he states about pills "helps the organism take in the insulin" is wrong as not all anti-diabetic drugs do this. Sulphonylureas, for instance, stimulate the pancreas to produce more insulin. To get to your question though, in type 2 diabetes mellitus (non-insulin dependent diabetes mellitus) the reason patients exhibit hyperinsulinemia is due to the insulin resistance that has built up in the body's cells. (This means that the body's cells aren't able to 'take in' glucose from the bloodstream.) To counter this, the body produces much more insulin than would otherwise be considered normal ...
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