Wednesday, May 28, 2008

How do diabetes mellitus contribute to diabetic nephropathy

How do diabetes mellitus contribute to diabetic nephropathy?

Diabetes - 6 Answers
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1 :
Diabetes can cause NEUROPATHY in the feet, meaning that people who suffer from diabetes can loose feeling in their feet. This is caused by poor circulation to the limbs, especially the lower extremities.
2 :
When the blood sugar is high, it damages the tiny blood vessels in the kidneys. Those blood vessels filter waste from the blood. When they get damaged from high blood sugar, the kidneys aren't able to do their job as well. Note to others: The question is about NEPHROpathy, not NEUROpathy
3 :
Neuropathy is a common name for complications affecting the nervous system. Diabetic neuropathy is long-term damage to the nerve fibres. It happens when high blood glucose levels are present over several years. In diabetes, the form it usually first takes is reduced sensation in the feet. The nerve damage affects each foot equally and eventually spreads up the legs. Poor sensation in your feet makes them more prone to injury. Combined with poor circulation this can easily lead to ulcers and infections. The nerve damage can be short term (acute) or long term (chronic): * acute neuropathy usually disappears once the diabetes is under control. It often presents as a burning sensation in the feet and is especially bad at night * chronic neuropathy has more serious implications. Because this complication is caused by poor blood sugar control, people who don't take enough care in controlling their diabetes stand a higher risk of developing nerve damage. An early sign of diabetic neuropathy is a lack of ability to feel vibrations, for example from a tuning fork. This test can be carried out during your annual diabetes check-up. The same sort of nerve damage can occur in the hands. This is uncommon, and is always accompanied by problems in the feet and legs. Unfortunately, this type of nerve damage is permanent. Once it's happened, it isn't improved by better control of diabetes.
4 :
High blood glucose (sugar) levels cause damage to the microcirculation, especially in the extremities. This in turn causes nerve damage and results in neuropathic pain.
5 :
Type 2 diabetics usually take Metformin. In many of us it causes a deficiency in B12. Which in turn contributes to diabetic neuropathy. Healthy Nerves Vitamin B12 is an especially important vitamin for maintaining healthy nerve cells and it aids in the production of DNA and RNA, the body's genetic material. Vitamin B12 also works closely together with folic acid to regulate formation of red blood cells
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